Researcher Profile Form First National Pediatric Brain Tumor Research Meeting March 9, 2025 - Jerusalem
Researcher: Prof. Yuval Ebenstein
Current Role & Affiliation
Title/Position: Head of NanoBioPhotonix Lab; Founder of the Tel Aviv University Entrepreneurship Center
Institution: Tel Aviv University
Email: uv@tauex.tau.ac.il
Phone: 054-3188316
Prof. Ebenstein leads the NanoBioPhotonix Lab, focusing on the intersection of chemistry, physics, biology, and bioinformatics for genomic research.
Research Focus
● Single molecule genomics by optical mapping:
● Epigenetic analysis technologies:
● High-throughput single molecule detection
Current Projects Related to Pediatric Brain Tumors
● DNA methylation-based brain tumor classification
● Liquid biopsy diagnostics for brain cancer
Laboratory/Research Resources
● Nano-technology tools for genomic research
● Advanced diagnostic platforms
Collaboration Interests
● Liquid biopsy development
● Genomic technology advancements
What You Can Offer Potential Collaborators
● Expertise in genomic diagnostics
● Nano-technology applications for healthcare
Selected Publications
1. Detinis Zur T, et.al. Single-molecule toxicogenomics: Optical genome mapping of DNA-damage in nanochannel arrays. DNA Repair (Amst). 2025 Jan 10;146:103808.
2. Margalit S, et.al.Long-read structural and epigenetic profiling of a kidney tumor-matched sample with nanopore sequencing and optical genome mapping. NAR Genom Bioinform. 2025 Jan 7;7(1):lqae190.
3. Yao B, Effective training of nanopore callers for epigenetic marks with limited labelled data. Open Biol. 2024 Jun;14(6):230449.
Keywords
Genomics, Nano-Technology, Liquid Biopsy, DNA Methylation
Brief Bio
Prof. Yuval Ebenstein is head of the NanoBioPhotonix Lab within the Department of Physical Chemistry at Tel Aviv University, and head of the European consortium BeyondSeq and Sanguine developing novel genomic technologies. Zooming in on individual components—single cells, single chromosomes and single molecules— Ebenstein’s interdisciplinary research aims to contribute to how we understand the human genome. Yuval earned B.S. degrees in Physics and Chemistry, and a Ph.D. in Physical Chemistry with Prof. Uri Banin, all from the Hebrew University in Jerusalem, Israel. He did a postdoc with Prof. Shimon Weiss at UCLA where he used QDs to light-up individual DNA binding proteins and map them along bacteriophage genomes
