Researcher Profile Form First National Pediatric Brain Tumor Research Meeting March 9, 2025 - Jerusalem
Researcher: Prof. Ruth Shemer
Current Role & Affiliation
Title/Position: Associate Professor, Faculty of Medicine, Department of Developmental Biology and Cancer Research
Institution: The Hebrew University of Jerusalem
Email: shemer.ru@mail.huji.ac.il
Phone: 052-8643153
Prof Shemer is a leading researcher in the Hebrew University in Jerusalem. through her ongoing collaboration with Prof Yuval dor and others she leads research on methylation patterns and their clinical applications.
Research Focus
● Methylation Profiles
● Liquid biopsy
● Developmental Biology
Current Projects Related to Pediatric Brain Tumors
● Methylation atlas
● Diagnosis of cancer stage through methylation profile
Laboratory/Research Resources
● molecular biology
● bioinformatic tools
What You Can Offer Potential Collaborators
experience and knowledge in building clinical tools using methylation profiles to diagnose and follow cancer
Keywords
Cell-free DNA (cfDNA), Liquid Biopsy,Cell Death, Cell of Origin, DNA Methylation Markers, Imprinted Genes, Demethylation, Cell Reprogramming, Differential Methylation
Recent Relevant Publications
1. Ochana BL, et.al. Time is encoded by methylation changes at clustered CpG sites.bioRxiv [Preprint]. 2024 Dec 5:2024.12.03.626674. doi: 10.1101/2024.12.03.626674.
2. Fox-Fisher I, et.al. Epigenetic liquid biopsies: a novel putative biomarker in immunology and inflammation. Trends Immunol. 2023 May;44(5):356-364. doi: 10.1016/j.it.2023.03.005. Epub 2023 Apr 1.
3. Grinshpun A, et.al. A universal cell-free DNA approach for response prediction to preoperative chemoradiation in rectal cancer. Int J Cancer. 2023 Apr 1;152(7):1444-1451.
Brief Bio
Prof Shemer, along with Prof. Yuval Dor is involved in multiple studies centering upon the development and clinical use of cell free DNA based methylation profiles as a tool to diagnose malignant tumors and follow them. Several such studies led to the availability of tools assessing the cell of origin of tumors which were unclassifiable based on current clinical methods. Prof Shemer participated in the development of a methylation tissue atlas of normal human cell types.
