Researcher Profile Form First National Pediatric Brain Tumor Research Meeting March 9, 2025 - Jerusalem
Researcher: Prof. Eran Meshorer
Current Role & Affiliation
Title/Position: Professor at The Hebrew University, The Arthur Gutterman Chair in Stem Cell Research
Institution: Department of Genetics and the Edmond and Lily Center for Brain Sciences (ELSC), The Hebrew University of Jerusalem
Email: meshorer@huji.ac.il
Phone: 054-3373238
Prof Meshorer leads a research laboratory in the Hebrew university in Jerusalem working on epigenetic pathways and modulation of stem cell development.
Research Focus
1. Epigenetic regulation in stem cells and differentiation;
2. Neurodegenerative diseases (e.g. HD) using pluripotent stem cell models;
3. Paleo-epigenetics: reconstructing DNA methylation in archaic genomes.
Current Projects Related to Pediatric Brain Tumors
Prof Meshorer has won an ICRF research grant for his work on alternative mechanisms in H3K27M high grade glioma
What You Can Offer Potential Collaborators
extensive experience in epigenetics in stem cells, neuronal differentiation and neurons; Modeling neurodegenerative diseases using pluripotent stem cells; Paleo-epigenetics: reconstructing methylation in ancient DNA; Live imaging of nuclear dynamics in stem cell differentiation; Signaling pathways and molecular networks in stem cells and cancer
Keywords
epigenetics, methylation, paleo-epigenetics, stem cell differentiation
Recent Relevant Publications
1. Cohen LRZ, et. al. .The many faces of H3.3 in regulating chromatin in embryonic stem cells and beyond.Trends Cell Biol. 2024 Dec;34(12):1044-1055. doi: 10.1016/j.tcb.2024.03.003. Epub 2024 Apr 13.PMID: 38614918
2. Viegas JO, et.al. .RNA degradation eliminates developmental transcripts during murine embryonic stem cell differentiation via CAPRIN1-XRN2. Dev Cell. 2022 Dec 19;57(24):2731-2744.e5. doi: 10.1016/j.devcel.2022.11.014. Epub 2022 Dec 9.PMID: 36495875 Free PMC article.
3. Cohen LRZ,et.al. PRC2-independent actions of H3.3K27M in embryonic stem cell differentiation.Nucleic Acids Res. 2023 Feb 28;51(4):1662-1673.
Brief Bio
Prof. Meshorer has a long-term interest in how stem cells self-renew and differentiate, and how these processes are regulated by the proteins that package nuclear DNA. He received his BSc, MSc and PhD degrees from the Hebrew University of Jerusalem, and returned there as a faculty member after postdoctoral training in stem cell biology at the National Cancer Institute of the US National Institutes of Health
