Researcher Profile Form First National Pediatric Brain Tumor Research Meeting March 9, 2025 - Jerusalem
Researcher: Dr. Yotam Drier
Current Role & Affiliation
Title/Position: Research Scientist
Institution: Hebrew University of Jerusalem
Email: yotam.drier@mail.huji.ac.il
Phone: 054-5421252
Dr. Yotam Drier focuses on understanding the role of epigenetic and chromosome topology alterations in cancer.
Research Focus
● Epigenetic alterations in cancer
● Chromosome topology and heterogeneity in oncogenesis
● Machine learning applications in genomic data analysis
● Identification of biomarkers and therapeutic targets
Current Projects Related to Pediatric Brain Tumors
● Integrative analysis of genomic, epigenomic, and transcriptional data
● Biomarker discovery for disease management
Laboratory/Research Resources
● Advanced sequencing and molecular technologies
● Machine learning for data integration
Collaboration Interests
● Genomic and epigenomic research
● Development of new biomarkers and therapies
What You Can Offer Potential Collaborators
● Expertise in integrative genomic analysis
● Data-driven insights for clinical applications
Selected Publications
1. Davis E,et.al. Enhancer landscape of lung neuroendocrine tumors reveals regulatory and developmental signatures with potential theranostic implications. Proc Natl Acad Sci U S A. 2024 Oct 8;121(41):e2405001121.
2. Davis D, et.al. Accurate estimation of pathway activity in single cells for clustering and differential analysis. Genome Res. 2024 Jul 23;34(6):925-936
3. Antman I, et.al. Simultaneous Mapping of Enhancers and Enhancer Rearrangements with Paired-End H3K27ac ChIP-seq. Methods Mol Biol. 2022;2535:131-140. doi: 10.1007/978-1-0716-2513-2_11.PMID: 35867228
Keywords
Epigenetics, Chromosome Topology, Biomarkers, Genomic Analysis
Brief Bio
Dr. Drier started his scientific career studying computer science, math, and physics. During his PhD, Dr. Drier focused on cancer genomics to apply these skills to better understand cancer. In his postdoctoral studies at Harvard Medical School, Dr. Drier expanded his expertise in epigenomics to study how epigenomic and topological alterations drive cancer. His lab at the Hebrew University Medical School combines cutting-edge experimental techniques and machine-learning approaches to systematically study the role of genomic and epigenomic alterations in cancer.
