Researcher Profile Form First National Pediatric Brain Tumor Research Meeting March 9, 2025 - Jerusalem
Researcher: Dr. Sivan Izraely
Current Role & Affiliation
Title/Position: Research Associate
Institution: The Hebrew University-Hadassah Medical Center
Email: si0881@gmail.com
Phone: 053-7552423
LinkedIn: linkedin.com/in/sivan-izraely-21261412a
Dr. Izraely conducts cancer research at The Hebrew University and Hadassah Medical Center, working in the labs of Prof. Yuval Tabach and Prof. Aron Popovtzer. Her research focuses on identifying genetic and epigenetic biomarkers to predict treatment responses and optimize therapeutic strategies.
Research Focus
● Cancer progression and metastasis
● Tumor-microenvironment interactions
● Genetic and epigenetic biomarkers
● Optimization of therapeutic strategies
Current Projects Related to Pediatric Brain Tumors
● Identification of biomarkers for treatment response
● Research on tumor-microenvironment interactions
Laboratory/Research Resources
● Xenograft models for brain metastasis
● Molecular biology and genomic analysis tools
Collaboration Interests
● Biomarker discovery for cancer therapy
● Translational research on metastasis mechanisms
What You Can Offer Potential Collaborators
● Expertise in cancer progression and metastasis
● Advanced xenograft models for therapeutic testing
Selected Publications
1. Adir O, et.al. Heterogeneity in the Metastatic Microenvironment: JunB-Expressing Microglia Cells as Potential Drivers of Melanoma Brain Metastasis Progression.cCancers (Basel). 2023 Oct 13;15(20):4979.
2. Izraely S, et.al. The Vicious Cycle of Melanoma-Microglia Crosstalk: Inter-Melanoma Variations in the Brain-Metastasis-Promoting IL-6/JAK/STAT3 Signaling Pathway.Cells. 2023 May 30;12(11):1513.
Keywords
Cancer Metastasis, Tumor Microenvironment, Genetic Biomarkers, Epigenetics
Brief Bio
Dr. Sivan Izraely is a cancer researcher with 19 years of experience specializing in cancer progression and metastasis. She earned her PhD in Cell Research and Immunology from Tel Aviv University under the supervision of Prof. Isaac Witz, where she also served as a research associate, focusing on melanoma brain metastasis and tumor-microenvironment interactions. Her work has significantly advanced the understanding of cancer progression, including developing xenograft models to study brain metastasis in melanoma. At The Hebrew University and Hadassah Medical Center, she conducts research in the labs of Prof. Yuval Tabach and Prof. Aron Popovtzer, focusing on genetic and epigenetic biomarkers to optimize cancer therapies.
