Researcher Profile Form First National Pediatric Brain Tumor Research Meeting March 9, 2025 - Jerusalem
Researcher: Dr. Ruty Mehrian-Shai
Current Role & Affiliation
Title/Position: Chief Scientist
Institution: The Brain Cancer Molecular Research Lab
Email: Rutyshai@gmail.com
Phone: 054-3938318
Dr. Mehrian-Shai heads the Brain Cancer Molecular Research Lab at Sheba Medical Center, focusing on precision molecular diagnostics and classification tools for better patient care in brain cancer.
Research Focus
● Liquid biopsy for brain tumor follow up
● With the support of Israel Innovation Authority Kamin grant funding, we have showed preclinical efficacy of a potential SiRNA treatment that can inhibit pediatric brain tumor growth and spread.
● Interrogation of the brain tumor ecosystem including metabolism, vasculature, immune responses and the microbiome.
● Novel approach in Nano-medicine: oral delivery of proteinoid nanocapsules containing synergistic drugs for personalized brain cancer
Current Projects Related to Pediatric Brain Tumors
● Development of blood-based assays for medulloblastoma diagnosis and monitoring
● Discovery of novel therapeutic targets for medulloblastoma subgroups
● Personalized medicine approaches for pediatric gliomas
Laboratory/Research Resources
● Molecular marker analysis
● Translational experiment platforms
Collaboration Interests
● Liquid biopsy advancements
● Novel antitumor agents
What You Can Offer Potential Collaborators
● Expertise in molecular diagnostics
● Preclinical research on therapeutic targets
Keywords
Liquid Biopsy, Molecular Diagnostics, Medulloblastoma, Pediatric Gliomas, siRNA
Recent Relevant Publications
1. Caller T, et.al. Extracellular Vesicles From Infarcted and Failing Heart Accelerate Tumor Growth.Circulation. 2024 May 28;149(22):1729-1748. doi: 10.1161/CIRCULATIONAHA.123.066911. Epub 2024 Mar
Brief Bio
Dr. Ruty Mehrian-Shai specializes in developing molecular diagnostic tools for precision medicine in brain cancer. she also involved in development of ansiRNA based therapies, specifically in medulloblasma
