Researcher Profile Form First National Pediatric Brain Tumor Research Meeting March 9, 2025 - Jerusalem
Researcher: Dr. Laila Roisman
Current Role & Affiliation
Title/Position: The director of the unit for personalized medicine and innovation in oncology
Institution: Shaare Zedek Medical Center
Email: dr.roisman@gmail.com
Phone: 054-2005129
Dr Roisman heads the Personalized medicine unit in Shaare Zedek Medical Center. she leads the effort to provide patients with evaluation of targeted therapies options and personalization of treatment.
Research Focus
● Drug development
● overcoming drug resistance mechanisms
● cell-cell communication
● improving cancer treatment decision-making.
Current Projects Related to Pediatric Brain Tumors
● Development of liquid biopsy panels
● facilitation of personal medicine
improving cancer treatment decision-making.
Laboratory/Research Resources
Dr Roisman leads a research laboratory involved in development of tools allowing the use of personalized approach to cancer therapy including methylation profiles, genetic sequencing and a variety of molecular panels.She is also interested in biobanking and tissue preservation.
Keywords
personalized medicine, drug development, biobanking, genomic panels, sequencing methods
Recent Relevant Publications
1. Fuchs V, et.al. Personalizing non-small cell lung cancer treatment through patient-derived xenograft models: preclinical and clinical factors for consideration.Clin Transl Oncol. 2024 Sep;26(9):2227-2239. doi: 10.1007/s12094-024-03450-3. Epub 2024 Mar 29.PMID:
2. Shemesh R, et.al. The interaction of mast cells with membranes from lung cancer cells induces the release of extracellular vesicles with a unique miRNA signature.Sci Rep. 2023 Dec 6;13(1):21544.
3. Roisman et.al. NR.Radiological artificial intelligence - predicting personalized immunotherapy outcomes in lung cancer.NPJ Precis Oncol. 2023 Nov 21;7(1):125.
Brief Bio
Dr. Laila C. Roisman, is the Previously, she was the Director of Oncology Research at Soroka University Medical Center and headed the bioinformatics and R&D at the Center for Precision Cancer Care at Rabin Medical Center, Israel. Dr. Roisman graduated with a PhD degree in biophysics from the Weizmann Institute of Science. She did her first post-doctoral training at the Weizmann Institute in high-throughput DNA repair functional assay development and a second post-doctoral training in immune protein crystallography at Monash University, Australia. Following that, she developed the Structural Neurobiology program at the University of Melbourne, in Australia.Dr. Roisman has more than 1000 citations and publications in leading journals, including Science, Immunity, PNAS, JMB and the grant of one international patent (licensed to a pharmaceutical company for further development)
