Researcher Profile Form First National Pediatric Brain Tumor Research Meeting March 9, 2025 - Jerusalem
Current Role & Affiliation
Title/Position: Principal Investigator
Institution: Weizmann Institute of Science
Email: tirosh.itay@gmail.com
Phone: 0549453547
Prof.Tirosh’s team had analyzed multiple types of adult and pediatric glioma by single cell RNA-seq, in collaboration with Mario Suva from MGH. For each type of glioma, we found distinct subpopulations of malignant cells. Our single cell analysis and follow up studies are helping to define the targets for both of these possibilities.
Research Focus
● Single-cell technologies
● Tumor heterogeneity
● Computational analysis of tumor samples
Current Projects Related to Pediatric Brain Tumors
● Analysis of cellular diversity in pediatric gliomas
● Spatial mapping of tumor samples
Laboratory/Research Resources
● Single-cell sequencing technologies
● Spatial transcriptomics
Collaboration Interests
● Single-cell tumor analysis
● Computational tumor modeling
What You Can Offer Potential Collaborators
● Expertise in single-cell and spatial analysis
● Computational insights into tumor diversity
Selected Publications
1. Tirosh I, et.al. Cancer cell states: Lessons from ten years of single-cell RNA-sequencing of human tumors. Cancer Cell. 2024 Sep 9;42(9):1497-1506.
2. Greenwald AC, et.al. Integrative spatial analysis reveals a multi-layered organization of glioblastoma. Cell. 2024 May 9;187(10):2485-2501.e26.
3. Gavish A, et.al. Hallmarks of transcriptional intratumour heterogeneity across a thousand tumours. Nature. 2023 Jun;618(7965):598-606.
Keywords
Single-Cell Analysis, Tumor Heterogeneity, Spatial Technologies
Brief Bio
Itay Tirosh obtained his BSc from Ben-Gurion University and his PhD from the Weizmann Institute of Science, both in the area of computational biology. From 2012 to 2017 he was a postdoctoral fellow at the Regev and Golub labs at the Broad Institute of MIT and Harvard, and since August 2017 he has been a Senior Scientist at the Weizmann Institute of Science, Dept. of Molecular Cell Biology.
The Tirosh lab is combining computational and experimental methods to study human tumors as a complex ecosystem in which diverse cancer and non-cancer cells interact and collectively determine tumor biology and response to therapies. They leverage single cell technologies, computational approaches and clinical collaborations to understand the diversity of cells within human tumors, the mechanisms that maintain this diversity and the implications for cancer therapy
