Researcher Profile Form First National Pediatric Brain Tumor Research Meeting March 9, 2025 - Jerusalem
Researcher: Dr. Elad Jacoby
Current Role & Affiliation
Title/Position: Head of the Pediatric Cell Therapy Center, Sheba Medical Center
Institution: Sheba Medical Center
Email: elad.jacoby@sheba.health.gov.il
Phone: 052-6668355
Dr. Elad Jacoby heads the cell therapy center of pediatrics at the Sheba Medical Center, and a senior lecturer in pediatrics. He is an expert in childhood leukemia and in CAR T cells, combining basic science knowledge of CAR T-cells, clinical trial design and patient management.
Dr Jacoby leads clinical trials in advanced cellular therapies including CAR T-cells and first-in-human mitochondrial augmentation.
Research Focus
Dr Jacoby is deeply involved in all aspects of CAR T cell treatment for rare pediatric diseases and pediatric cancer
Current Projects Related to Pediatric Brain Tumors
CAR T cell therapy for CNS leukemia and its application to treatment of CNS malignancies
What You Can Offer Potential Collaborators
Extensive experience in preclinical and clinical research in CAR T Celll immunotherapy.
Keywords
CAR T Cells, cancer cellular immunotherapy, mitochondrial disease
Recent Relevant Publications
1. Rossig C, et.al. Chimeric Antigen Receptor (CAR) T-Cell Products for Pediatric Cancers: Why Alternative Development Paths Are Needed. J Clin Oncol. 2024 Jan 20;42(3):253-257.
2. Gross G, et.al. .Improved CAR-T cell activity associated with increased mitochondrial function primed by galactose. bioRxiv [Preprint]. 2023 Sep 25:2023.09.23.559091.
3. Jacoby E, et.al. Parameters of long-term response with CD28-based CD19 chimaeric antigen receptor-modified T cells in children and young adults with B-acute lymphoblastic leukaemia.Br J Haematol. 2022 May;197(4):475-481.
Brief Bio
Dr. Elad Jacoby graduated from the Tel Aviv University, and completed the pediatric residency at the Sheba Medical Center, Israel, and Pediatric Hematology and Oncology fellowship at the Johns Hopkins Hospital and the National Cancer Institute, MD, USA. He completed a cell therapy clinical and research fellowship at the National Cancer Center.
Dr. Jacoby heads the cell therapy center in Pediatrics at the Sheba Medical Center, and is a Senior Lecturer in Pediatrics at the Faculty of Medicine, Tel Aviv University. He is a board certified pediatric hematologist and oncologist, and an expert in childhood leukemia and in CAR T cells.
His research interests include CAR T-cell clinical applications, leading international clinical trials in the field; Biology of CAR T-cells, leading translational lab-based research; and mitochondrial augmentation, leading the preclinical development and the first-in-human clinical trial of MAT in patients
